RS case 1 - Bronchiectasis

Case Presentation: Bronchiectasis

Identification Data

  • Name: Mr. Rajesh Kumar

  • Age/Sex: 52 years/Male

  • Education : 10th pass

  • Occupation: Farmer

  • Address: Rural West Bengal

  • Date of admission :

  • Date of examination :

  • Informant : Patient himself

Presenting Complaints

  • Chronic productive cough with thick, foul-smelling, greenish sputum (~3/4 cup/day), for 8 years

  • Progressive breathlessness (MMRC I → 4), for 4 years

  • Recurrent hemoptysis (5–6 episodes/year), for 3 years

History of Present Illness

Mr. Rajesh Kumar, a 52-year-old male, reports that his symptoms began insidiously about eight years ago (onset and duration) with a persistent cough. Over time, this cough became increasingly productive (progression), with expectoration of thick, foul-smelling, greenish sputum, amounting to nearly three-fourths of a cup daily (associated symptoms) . He observed that the sputum often settled into three layers when left to stand. The cough is present throughout the day but tends to worsen in the mornings and during episodes of weather change (diurnal and seasonal variation). Patient also experiences more cough in lying down position mostly at night.(positional variation). Patient feels a sense of relief after expectoration.(aggravating and relieving factors)

He also describes progressive breathlessness for the last four years, which initially occurred on exertion (MMRC class 1) but has gradually worsened to the point where he now feels breathless even at rest during exacerbations (MMRC class 4). Patient initially could go to fields but for the last 3 months rarely leaves home due to breathlessness.

Over the past three years, he has experienced recurrent episodes of hemoptysis, each episode involving bright red blood mixed with sputum, typically about 10–20 mL, without clots, and occurring about five to six times per year. All the episodes were self limiting and most of the episodes were during the periods of increased sputum production and low grade fever.

Over the last two years, he has noticed significant weight loss of approximately eight kilograms, along with fatigue and reduced exercise tolerance.

He does not report any chest pain, palpitations, orthopnea, paroxysmal nocturnal dyspnea, or swelling of the legs. There is no history of night sweats or drenching sweats. He has not experienced any episodes of syncope, seizures, or neurological symptoms. He denies any history of skin rashes, joint pains, or symptoms suggestive of connective tissue disease. There is no history of recurrent sinusitis, ear discharge, or features suggestive of immunodeficiency. He has not noticed any change in voice, dysphagia, or symptoms suggestive of upper airway involvement.

Past History

  • Treated pulmonary tuberculosis 15 years ago (completed ATT)

  • Multiple episodes of pneumonia in childhood

  • No history of asthma, diabetes, or hypertension

Family History

  • Father had chronic bronchitis

  • No known consanguinity or cystic fibrosis or similar illness in siblings.

  • No h/o any lung malignancy in family

Personal History

  • Normal sleep and appetite

  • Smoker: Bidi, 1 pack/day for 25 years (quit 3 years ago)

  • Occasional alcohol use

  • Occupational exposure to rice husk dust and biomass smoke

Socioeconomic History

  • Lives in a rural area, poor ventilation, limited access to healthcare

  • Kutcha house, 6 membered family with 2 rooms, overcrowding present

  • Uses wood for cooking

  • Drinks water from sanitary well

General Examination

  • Patient conscious, oriented, cooperative

  • Thin, undernourished (BMI 16.2 kg/m²)

  • Pallor present,

  • Grade 4 (drumstick) clubbing of fingers

  • No cyanosis, icterus or lymphadenopathy

  • Vitals: PR 102/min, regular, increased volume and normal character, no radio-radial or radio-femoral delay

  • BP 110/70 mmHg in right upper limb in sitting position

  • RR 24/min, abdomino-thorasic

  • Temp 99.8°F

  • SpO₂ 91% (room air)

Upper Respiratory Examination

  • Deviated nasal septum to the left

  • No nasal polyps or sinus tenderness

  • Tonsils and posterior pharyngeal wall normal

  • Postnasal drip present

Respiratory System Examination

Inspection

  • Shape of chest :Barrel-shaped chest

  • Chest appears bilaterally symmetrical

  • Trachea appears to be central

  • Apical impulse visible in 5th left intercostal space in mid clavicular line

  • Respiratory movements appears reduced right upper chest

  • Old scar in right infraclavicular region

  • Use of accessory muscles, visible bronchial tug

Palpation

  • No rise in temperature or tenderness

  • Inspection findings confirmed by palpation

  • Trachea central

  • Apex beat palpable in 5th left intercostal space in mid clavicular line

  • Respiratory movements are reduced in right lower zone, normal in all other areas

  • Chest expansion 5.5 cm, Right hemithorax expansion 2 cm and left hemithorax expansion 3.5 cm

  • AP diameter : 21 cm and transverse diameter : 23 cm

Percussion

  • Supraclavicular: Resonant b/l

  • Clavicular: impaired resonance on right

  • Infraclavicular: Impaired resonance on right (s/o consolidation)

  • Mammary: Dullness at right 5th ICS

  • Axillary: Normal bilaterally

  • Infra-axillary: Resonant b/l

  • Suprascapular: Resonant b/l

  • Interscapular: Resonant

  • Infrascapular: impaired resonance in right side (s/o consolidation)

Auscultation

  • Supraclavicular: Coarse crackles (right)

  • Clavicular: Bronchial breath sounds (right 2nd ICS) (s/o consolidation)

  • Infraclavicular: Bronchial breathsounds (right) (s/o consolidation)

  • Mammary: Amphoric breath sounds, egophony (right 5th ICS) (s/o cavitation)

  • Axillary: Prolonged expiration, polyphonic wheezes

  • Infra-axillary: Coarse crackles, reduced air entry (right)

  • Suprascapular: Normal vesicular sounds

  • Interscapular: Bronchovesicular sounds (right T6–T8)(normal variant)

  • Infrascapular: Coarse inspiratory crackles, increased vocal resonance (right) (s/o consolidation)

Summary

Mr. Rajesh Kumar, a 52-year-old male with a history of treated pulmonary tuberculosis and significant environmental exposures, presents with chronic productive cough, recurrent hemoptysis, progressive dyspnea, and constitutional symptoms. Examination reveals clubbing, focal bronchial breath sounds, amphoric resonance, and persistent coarse crackles predominantly in the right lung zones. The clinical picture is most consistent with post-tubercular bronchiectasis involving the right middle and lower lobes, with possible complications such as secondary infection or localized cavitation. Further evaluation with sputum studies, high-resolution CT chest, and pulmonary function tests is warranted to confirm the diagnosis and guide management.


Viva Questions on Bronchiectasis

Definition & Pathophysiology

1. What is bronchiectasis?
Bronchiectasis is a chronic lung disease characterized by irreversible dilatation and destruction of the bronchial walls due to chronic infection and inflammation.

2. Describe the pathogenesis of bronchiectasis.
It begins with an insult to the bronchial wall (such as infection), leading to impaired mucociliary clearance, persistent infection, chronic inflammation, and progressive destruction and dilatation of the airways.

3. What is the “vicious cycle” hypothesis in bronchiectasis?
It refers to the cycle of airway damage, impaired clearance, infection, and inflammation, which perpetuates further airway damage.

Etiology & Risk Factors

4. What are the common causes of bronchiectasis?

  • Post-infective (pneumonia, tuberculosis)

  • Cystic fibrosis

  • Primary ciliary dyskinesia

  • Immunodeficiency states

  • Allergic bronchopulmonary aspergillosis (ABPA)

  • Obstruction (tumor, foreign body)

5. How does tuberculosis cause bronchiectasis?
Tuberculosis can cause bronchiectasis by causing fibrosis and stenosis of bronchi, leading to traction and dilatation of distal airways.

6. Name some congenital causes of bronchiectasis.
Cystic fibrosis, primary ciliary dyskinesia, and Kartagener syndrome.

Clinical Features

7. What are the typical symptoms of bronchiectasis?
Chronic productive cough with copious, purulent sputum, recurrent hemoptysis, breathlessness, and sometimes chest pain.

8. What is characteristic about the sputum in bronchiectasis?
The sputum is often voluminous, purulent, foul-smelling, and may settle into three layers on standing.

9. What are the important signs on physical examination?
Clubbing of fingers, coarse inspiratory crackles (especially at lung bases), rhonchi, and sometimes signs of respiratory failure.

Diagnosis

10. What is the investigation of choice for diagnosing bronchiectasis?
High-resolution computed tomography (HRCT) of the chest.

11. What are the typical findings on HRCT in bronchiectasis?
Dilated bronchi with thickened walls, signet ring sign, tram-track appearance, and lack of bronchial tapering.

12. What microbiological investigations are important?
Sputum Gram stain and culture, acid-fast bacilli staining, and fungal cultures.

13. What tests are done to find the underlying cause?
Sweat chloride test, immunoglobulin levels, ciliary function tests, and tests for ABPA.

Management

14. What are the main goals of treatment in bronchiectasis?
Control infection, enhance airway clearance, reduce inflammation, and treat underlying cause.

15. What airway clearance techniques are used?
Chest physiotherapy, postural drainage, active cycle of breathing techniques, and use of devices like flutter valve.

16. When are antibiotics indicated?
During acute exacerbations, or as long-term suppressive therapy in patients with frequent exacerbations or chronic colonization with pathogens.

17. What is the role of bronchodilators and corticosteroids?
Bronchodilators are useful if there is associated airway hyperreactivity; inhaled corticosteroids may be considered in patients with coexisting asthma or ABPA.

18. When is surgery indicated in bronchiectasis?
Surgery is considered for localized disease not controlled by medical management, or for life-threatening hemoptysis.

Complications

19. What are the complications of bronchiectasis?
Massive hemoptysis, respiratory failure, cor pulmonale, lung abscess, and amyloidosis.

20. How does bronchiectasis lead to cor pulmonale?
Chronic hypoxia causes pulmonary vasoconstriction, leading to pulmonary hypertension and right heart failure.

Special Types & Differential Diagnosis

21. What is cystic fibrosis and how is it related to bronchiectasis?
Cystic fibrosis is a genetic disorder causing thick, sticky mucus production, leading to recurrent infections and bronchiectasis, especially in children and young adults.

22. What is ABPA and how does it cause bronchiectasis?
Allergic bronchopulmonary aspergillosis is a hypersensitivity reaction to Aspergillus species, leading to central bronchiectasis and mucus plugging.

23. How do you differentiate bronchiectasis from COPD?
Bronchiectasis is characterized by copious purulent sputum and frequent infections, with HRCT showing bronchial dilatation, whereas COPD shows airflow limitation with emphysema or chronic bronchitis features.

24. What is Kartagener syndrome?
It is a triad of situs inversus, chronic sinusitis, and bronchiectasis, due to primary ciliary dyskinesia.

25. What is the significance of “dry bronchiectasis”?
It refers to bronchiectasis presenting with hemoptysis but little or no sputum production, often seen in post-tubercular cases.

Prognosis and Prevention

26. What factors indicate a poor prognosis in bronchiectasis?
Frequent exacerbations, chronic Pseudomonas colonization, extensive disease, and presence of respiratory failure.

27. How can bronchiectasis be prevented?
Prompt treatment of respiratory infections, immunization, early diagnosis and management of underlying conditions, and avoiding smoking and environmental pollutants