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RS case 1 - Bronchiectasis
Case Presentation: Bronchiectasis
Identification Data
Name: Mr. Rajesh Kumar
Age/Sex: 52 years/Male
Education : 10th pass
Occupation: Farmer
Address: Rural West Bengal
Date of admission :
Date of examination :
Informant : Patient himself
Presenting Complaints
Chronic productive cough with thick, foul-smelling, greenish sputum (~3/4 cup/day), for 8 years
Progressive breathlessness (MMRC I → 4), for 4 years
Recurrent hemoptysis (5–6 episodes/year), for 3 years
History of Present Illness
Mr. Rajesh Kumar, a 52-year-old male, reports that his symptoms began insidiously about eight years ago (onset and duration) with a persistent cough. Over time, this cough became increasingly productive (progression), with expectoration of thick, foul-smelling, greenish sputum, amounting to nearly three-fourths of a cup daily (associated symptoms) . He observed that the sputum often settled into three layers when left to stand. The cough is present throughout the day but tends to worsen in the mornings and during episodes of weather change (diurnal and seasonal variation). Patient also experiences more cough in lying down position mostly at night.(positional variation). Patient feels a sense of relief after expectoration.(aggravating and relieving factors)
He also describes progressive breathlessness for the last four years, which initially occurred on exertion (MMRC class 1) but has gradually worsened to the point where he now feels breathless even at rest during exacerbations (MMRC class 4). Patient initially could go to fields but for the last 3 months rarely leaves home due to breathlessness.
Over the past three years, he has experienced recurrent episodes of hemoptysis, each episode involving bright red blood mixed with sputum, typically about 10–20 mL, without clots, and occurring about five to six times per year. All the episodes were self limiting and most of the episodes were during the periods of increased sputum production and low grade fever.
Over the last two years, he has noticed significant weight loss of approximately eight kilograms, along with fatigue and reduced exercise tolerance.
He does not report any chest pain, palpitations, orthopnea, paroxysmal nocturnal dyspnea, or swelling of the legs. There is no history of night sweats or drenching sweats. He has not experienced any episodes of syncope, seizures, or neurological symptoms. He denies any history of skin rashes, joint pains, or symptoms suggestive of connective tissue disease. There is no history of recurrent sinusitis, ear discharge, or features suggestive of immunodeficiency. He has not noticed any change in voice, dysphagia, or symptoms suggestive of upper airway involvement.
Past History
Treated pulmonary tuberculosis 15 years ago (completed ATT)
Multiple episodes of pneumonia in childhood
No history of asthma, diabetes, or hypertension
Family History
Father had chronic bronchitis
No known consanguinity or cystic fibrosis or similar illness in siblings.
No h/o any lung malignancy in family
Personal History
Normal sleep and appetite
Smoker: Bidi, 1 pack/day for 25 years (quit 3 years ago)
Occasional alcohol use
Occupational exposure to rice husk dust and biomass smoke
Socioeconomic History
Lives in a rural area, poor ventilation, limited access to healthcare
Kutcha house, 6 membered family with 2 rooms, overcrowding present
Uses wood for cooking
Drinks water from sanitary well
General Examination
Patient conscious, oriented, cooperative
Thin, undernourished (BMI 16.2 kg/m²)
Pallor present,
Grade 4 (drumstick) clubbing of fingers
No cyanosis, icterus or lymphadenopathy
Vitals: PR 102/min, regular, increased volume and normal character, no radio-radial or radio-femoral delay
BP 110/70 mmHg in right upper limb in sitting position
RR 24/min, abdomino-thorasic
Temp 99.8°F
SpO₂ 91% (room air)
Upper Respiratory Examination
Deviated nasal septum to the left
No nasal polyps or sinus tenderness
Tonsils and posterior pharyngeal wall normal
Postnasal drip present
Respiratory System Examination
Inspection
Shape of chest :Barrel-shaped chest
Chest appears bilaterally symmetrical
Trachea appears to be central
Apical impulse visible in 5th left intercostal space in mid clavicular line
Respiratory movements appears reduced right upper chest
Old scar in right infraclavicular region
Use of accessory muscles, visible bronchial tug
Palpation
No rise in temperature or tenderness
Inspection findings confirmed by palpation
Trachea central
Apex beat palpable in 5th left intercostal space in mid clavicular line
Respiratory movements are reduced in right lower zone, normal in all other areas
Chest expansion 5.5 cm, Right hemithorax expansion 2 cm and left hemithorax expansion 3.5 cm
AP diameter : 21 cm and transverse diameter : 23 cm
Percussion
Supraclavicular: Resonant b/l
Clavicular: impaired resonance on right
Infraclavicular: Impaired resonance on right (s/o consolidation)
Mammary: Dullness at right 5th ICS
Axillary: Normal bilaterally
Infra-axillary: Resonant b/l
Suprascapular: Resonant b/l
Interscapular: Resonant
Infrascapular: impaired resonance in right side (s/o consolidation)
Auscultation
Supraclavicular: Coarse crackles (right)
Clavicular: Bronchial breath sounds (right 2nd ICS) (s/o consolidation)
Infraclavicular: Bronchial breathsounds (right) (s/o consolidation)
Mammary: Amphoric breath sounds, egophony (right 5th ICS) (s/o cavitation)
Axillary: Prolonged expiration, polyphonic wheezes
Infra-axillary: Coarse crackles, reduced air entry (right)
Suprascapular: Normal vesicular sounds
Interscapular: Bronchovesicular sounds (right T6–T8)(normal variant)
Infrascapular: Coarse inspiratory crackles, increased vocal resonance (right) (s/o consolidation)
Summary
Mr. Rajesh Kumar, a 52-year-old male with a history of treated pulmonary tuberculosis and significant environmental exposures, presents with chronic productive cough, recurrent hemoptysis, progressive dyspnea, and constitutional symptoms. Examination reveals clubbing, focal bronchial breath sounds, amphoric resonance, and persistent coarse crackles predominantly in the right lung zones. The clinical picture is most consistent with post-tubercular bronchiectasis involving the right middle and lower lobes, with possible complications such as secondary infection or localized cavitation. Further evaluation with sputum studies, high-resolution CT chest, and pulmonary function tests is warranted to confirm the diagnosis and guide management.
Viva Questions on Bronchiectasis
Definition & Pathophysiology
1. What is bronchiectasis?
Bronchiectasis is a chronic lung disease characterized by irreversible dilatation and destruction of the bronchial walls due to chronic infection and inflammation.
2. Describe the pathogenesis of bronchiectasis.
It begins with an insult to the bronchial wall (such as infection), leading to impaired mucociliary clearance, persistent infection, chronic inflammation, and progressive destruction and dilatation of the airways.
3. What is the “vicious cycle” hypothesis in bronchiectasis?
It refers to the cycle of airway damage, impaired clearance, infection, and inflammation, which perpetuates further airway damage.
Etiology & Risk Factors
4. What are the common causes of bronchiectasis?
Post-infective (pneumonia, tuberculosis)
Cystic fibrosis
Primary ciliary dyskinesia
Immunodeficiency states
Allergic bronchopulmonary aspergillosis (ABPA)
Obstruction (tumor, foreign body)
5. How does tuberculosis cause bronchiectasis?
Tuberculosis can cause bronchiectasis by causing fibrosis and stenosis of bronchi, leading to traction and dilatation of distal airways.
6. Name some congenital causes of bronchiectasis.
Cystic fibrosis, primary ciliary dyskinesia, and Kartagener syndrome.
Clinical Features
7. What are the typical symptoms of bronchiectasis?
Chronic productive cough with copious, purulent sputum, recurrent hemoptysis, breathlessness, and sometimes chest pain.
8. What is characteristic about the sputum in bronchiectasis?
The sputum is often voluminous, purulent, foul-smelling, and may settle into three layers on standing.
9. What are the important signs on physical examination?
Clubbing of fingers, coarse inspiratory crackles (especially at lung bases), rhonchi, and sometimes signs of respiratory failure.
Diagnosis
10. What is the investigation of choice for diagnosing bronchiectasis?
High-resolution computed tomography (HRCT) of the chest.
11. What are the typical findings on HRCT in bronchiectasis?
Dilated bronchi with thickened walls, signet ring sign, tram-track appearance, and lack of bronchial tapering.
12. What microbiological investigations are important?
Sputum Gram stain and culture, acid-fast bacilli staining, and fungal cultures.
13. What tests are done to find the underlying cause?
Sweat chloride test, immunoglobulin levels, ciliary function tests, and tests for ABPA.
Management
14. What are the main goals of treatment in bronchiectasis?
Control infection, enhance airway clearance, reduce inflammation, and treat underlying cause.
15. What airway clearance techniques are used?
Chest physiotherapy, postural drainage, active cycle of breathing techniques, and use of devices like flutter valve.
16. When are antibiotics indicated?
During acute exacerbations, or as long-term suppressive therapy in patients with frequent exacerbations or chronic colonization with pathogens.
17. What is the role of bronchodilators and corticosteroids?
Bronchodilators are useful if there is associated airway hyperreactivity; inhaled corticosteroids may be considered in patients with coexisting asthma or ABPA.
18. When is surgery indicated in bronchiectasis?
Surgery is considered for localized disease not controlled by medical management, or for life-threatening hemoptysis.
Complications
19. What are the complications of bronchiectasis?
Massive hemoptysis, respiratory failure, cor pulmonale, lung abscess, and amyloidosis.
20. How does bronchiectasis lead to cor pulmonale?
Chronic hypoxia causes pulmonary vasoconstriction, leading to pulmonary hypertension and right heart failure.
Special Types & Differential Diagnosis
21. What is cystic fibrosis and how is it related to bronchiectasis?
Cystic fibrosis is a genetic disorder causing thick, sticky mucus production, leading to recurrent infections and bronchiectasis, especially in children and young adults.
22. What is ABPA and how does it cause bronchiectasis?
Allergic bronchopulmonary aspergillosis is a hypersensitivity reaction to Aspergillus species, leading to central bronchiectasis and mucus plugging.
23. How do you differentiate bronchiectasis from COPD?
Bronchiectasis is characterized by copious purulent sputum and frequent infections, with HRCT showing bronchial dilatation, whereas COPD shows airflow limitation with emphysema or chronic bronchitis features.
24. What is Kartagener syndrome?
It is a triad of situs inversus, chronic sinusitis, and bronchiectasis, due to primary ciliary dyskinesia.
25. What is the significance of “dry bronchiectasis”?
It refers to bronchiectasis presenting with hemoptysis but little or no sputum production, often seen in post-tubercular cases.
Prognosis and Prevention
26. What factors indicate a poor prognosis in bronchiectasis?
Frequent exacerbations, chronic Pseudomonas colonization, extensive disease, and presence of respiratory failure.
27. How can bronchiectasis be prevented?
Prompt treatment of respiratory infections, immunization, early diagnosis and management of underlying conditions, and avoiding smoking and environmental pollutants